A Strategy for the Commons: Business-driven Networks for Collective Action and Policy Dialogue. The Example of Global Compact Local Networks

The current challenges involved with ensuring global sustainability are daunting. Climate change is increasing the incidence of severe weather events, natural resources are undergoing rapid depletion, labor conditions in global supply chains are often inhumane and degrading, and corruption around the globe is undermining competition and destroying wealth. These and other global challenges pose serious problems not only to mankind in general, but also to the sustainability of companies. Indeed, companies rely on enabling environments, local and global alike, for long-term success. Companies depend on a reliable legal framework conducive to investment and competition, a healthy and viable natural environment, and a secure social environment that facilitates the wellbeing of its inhabitants. However, given the overexploitation of shared resources, also known as the “tragedy of the commons,” companies often find it difficult to address global sustainability challenges and invest in enabling environments. All sustainability challenges face this tragedy: Although each societal actor ought to have an interest in creating or ensuring the viability of these common goods, the incentive to “free ride” on the efforts of others and let them bear the costs is exceedingly high. As a result, short-term profit maximization often damages the longterm growth prospects of companies. Since governments lack the capacity to address the complexity and global scope of sustainability challenges alone, a “strategy for the commons” is needed that allows companies, governments and other actors to overcome the free rider dilemma and invest in sustainable development

Treatment Response in Couple Therapy: Relationship Adjustment and Individual Functioning Change Processes

This study, a naturalistic investigation of the process of change in relationship adjustment and individual functioning during conjoint therapy, examined the first 8 sessions of a multisystemic model of couple therapy, integrative problem-centered metaframeworks (Breunlin, Pinsof, Russell, & Lebow, 2011; Pinsof, Breunlin, Russell, & Lebow, 2011). The sample consisted of 125 heterosexual couples who reported on their relationship adjustment and individual functioning before every session using the Systemic Therapy Inventory of Change (Pinsof et al., 2009; Pinsof, Zinbarg, et al., in press). Data were analyzed using dyadic latent growth curve and cross-lagged models. For both men and women, relationship adjustment and individual functioning showed nonlinear change, increasing during Sessions 1–4 and stabilizing during Sessions 5–8. At pretreatment, women reported lower levels of relationship adjustment than men; no gender differences existed in initial levels of individual functioning or in the change trajectories of relationship adjustment or individual functioning. Higher relationship adjustment predicted positive change in individual functioning for men (but not for women). In contrast, there were no cross-lagged effects of individual functioning on relationship adjustment for men or women. The results demonstrate the importance of examining the processes by which relational and individual pathology respond to couple-based interventions

Rapid testing leads to the underestimation of the scrapie prevalence in an affected sheep and goat flock

To obtain a more detailed understanding of the prevalence of classical scrapie infections in a heavily affected German sheep flock (composed of 603 sheep and 6 goats), we analysed 169 sheep and 6 goats that carried the genotypes susceptible to the disease and that were therefore culled following discovery of the index case. The initial tests were performed using the Biorad TeSeE ELISA and reactive results were verified by official confirmatory methods (OIE-immunoblot and/or immunohistochemistry (IHC)) to demonstrate the deposition of scrapie-associated PrPSc in the brain stem (obex). This approach led to the discovery of 40 additional subclinically scrapie-infected sheep. Furthermore, peripheral lymphatic and nervous tissue samples of the 129 sheep and 6 goats with a negative CNS result were examined by IHC in order to identify any preclinical infections which had not already spread to the central nervous system (CNS). Using this approach we found 13 additional sheep with PrPSc depositions in the gut-associated lymph nodes (GALT) as well as in the enteric nervous system. Moreover, in most of these cases PrPSc was also deposited in the spleen and in the retropharyngeal and superficial cervical lymph nodes. Taken together, these results show a 30.3% infection prevalence in this scrapie-affected flock. Almost 7.4% of the infected animals harboured PrPSc exclusively in the peripheral lymphatic and nervous tissue and were therefore missed by the currently used testing strategy

Adaptation of the Australian Palliative Care Phase concept to the German palliative care context: a mixed-methods approach using cognitive interviews and cross-sectional data

BACKGROUND Palliative care phases (stable, unstable, deteriorating, terminal and bereavement) are routinely used in Australia and the UK to describe the clinical situation of patients and their families and to evaluate the associated care plan. In addition, it serves as a benchmark developed by the Australian Palliative Care Outcome Collaboration (PCOC) and is used nationwide for comparisons between services. In Germany, the concept is not used consistently due to various translations. Furthermore, there is no nationwide systematic approach to routinely assess clinical outcomes in palliative care. The study aims to develop a German version of the palliative care phase definitions by adapting them culturally, and to examine the inter-rater reliability of the adjusted definitions with healthcare professionals. METHODS Mixed-methods approach: Cognitive interview study using 'think aloud' and verbal probing techniques and a consecutive multi-center cross-sectional study with two clinicians independently assigning the phase definitions. Interviewees/participants were selected through convenience and purposive sampling in specialist palliative care inpatient units, advisory and community services and in three specialist palliative care units with doctors, nursing staff and allied health professionals. RESULTS Fifteen interviews were conducted. Identified difficulties were: Some translated terms were 1) not self-explanatory (e.g. 'family/carer' or 'care plan') and (2) too limited to the medical dimension neglecting the holistic approach of palliative care. (3) Problems of comprehension regarding the concept in general occurred, e.g. in differentiating between the 'unstable' and 'deteriorating' phase. Inter-rater reliability was moderate (kappa = 0.44; 95% CI = 0.39-0.52). The assignment of the phase 'deteriorating' has caused the most difficulties. CONCLUSION Overall, the adapted palliative care phases are suitable to use in the German specialist palliative care setting. However, the concept of the phases is not self-explanatory. To implement it nationwide for outcome measurement/benchmarking, it requires further education, on-the-job training and experience as well as the involvement of healthcare professionals in implementation process. For the use of international concepts in different healthcare systems, a deeper discussion and cultural adaptation is necessary besides the formal translation

Stream sediment analysis for Lithium (Li) exploration in the Douro region (Portugal): A comparative study of the spatial interpolation and catchment basin approaches

Lithium (Li) was recently added to the list of critical raw materials by the European Union due to its significance for the green energy transition. Thus, the development of new toolchains to make Li exploration more economic and more effective is needed. Stream sediment analysis can play an important part in these new tool chains. In this work, two historical stream sediment datasets covering parts of the Fregeneda-Almendra pegmatite field in the Douro region (Portugal) were reprocessed considering two distinct approaches: spatial interpolation through inverse distance weighting (IDW) and the catchment basin approach using the concentration area (C-A) fractal analysis. The following objectives were delineated: (i) determine pathfinder elements for Li, considering relevant associations in the mineralization sources; (ii) compare the performance of both approaches; (iii) identify new target areas for Li. In the case of spatial interpolation, the highest Li values were associated to granites although the use of key elements allowed lithological discrimination and the delineation of target areas. In the catchment basin approach, fractal analysis proved to be effective in decreasing the number of areas of interest with high accuracy (>75%) when considering the previously mapped Li-pegmatites. One of the limitations identified was the number of anomalous basins related to the granites, despite the use of pathfinder elements allowing discriminating granite- from pegmatite-related Li anomalies. Comparing the two approaches, the spatial interpolation method is more adequate for the early stages of exploration (reconnaissance), while the catchment basin approach is more suited for prospect-scale exploration. Field validation of the results identified one pegmatite containing Li mineralization and three others with favorable signs for Li mineralization in the Douro region.The authors would like to thank the financial support provided by FCT– Fundação para a Ciência e a Tecnologia, I.P. (Portugal) and BMBF Jülich – Bundesministerium für Bildung und Forschung (Germany), with the ERA-MIN/0001/2017 – LIGHTS project. The work was also supported by Portuguese National Funds through the FCT projects UIDB/04683/2020 and UIDP/04683/2020 – ICT (Institute of Earth Sciences) and UIDB/50019/2020 – IDL (Instituto Dom Luiz). Joana Cardoso-Fernandes and Jéssica Lima are financially supported within the compass of their respective Ph.D. Thesis, ref. SFRH/BD/136108/2018 and ref. 2020.05793.BD, by national funds from MCTES through FCT, and co-financed by the European Social Fund (ESF) through POCH – Programa Operacional Capital Humano – and NORTE 2020 regional program. The Spanish Ministerio de Ciencia, Innovacion y Universidades (Project RTI2018-094097-B-100, with ERDF funds) and the University of the Basque Country (UPV/EHU) (grant GIU18/084) also contributed economically. The authors are also grateful to BRGM (Bureau de Recherches Géologiques et Minières) and LNEG (Laboratório Nacional de Energia e Geologia) for making the data available for this study

Reversible relative periodic orbits

AbstractWe study the bundle structure near reversible relative periodic orbits in reversible equivariant systems. In particular we show that the vector field on the bundle forms a skew product system, by which the study of bifurcation from reversible relative periodic solutions reduces to the analysis of bifurcation from reversible discrete rotating waves. We also discuss possibilities for drifts along group orbits. Our results extend those recently obtained in the equivariant context by B. Sandstede et al. (1999, J. Nonlinear Sci.9, 439–478) and C. Wulff et al. (2001, Ergodic Theory Dynam. Systems21, 605–635)

Maternal plasma levels of oxytocin during physiological childbirth - a systematic review with implications for uterine contractions and central actions of oxytocin

Oxytocin is a key hormone in childbirth, and synthetic oxytocin is widely administered to induce or speed labour. Due to lack of synthetized knowledge, we conducted a systematic review of maternal plasma levels of oxytocin during physiological childbirth, and in response to infusions of synthetic oxytocin, if reported in the included studies. An a priori protocol was designed and a systematic search was conducted in PubMed, CINAHL, and PsycINFO in October 2015. Search hits were screened on title and abstract after duplicates were removed (n = 4039), 69 articles were examined in full-text and 20 papers met inclusion criteria. As the articles differed in design and methodology used for analysis of oxytocin levels, a narrative synthesis was created and the material was categorised according to effects. Basal levels of oxytocin increased 3-4-fold during pregnancy. Pulses of oxytocin occurred with increasing frequency, duration, and amplitude, from late pregnancy through labour, reaching a maximum of 3 pulses/10 min towards the end of labour. There was a maximal 3- to 4-fold rise in oxytocin at birth. Oxytocin pulses also occurred in the third stage of labour associated with placental expulsion. Oxytocin peaks during labour did not correlate in time with individual uterine contractions, suggesting additional mechanisms in the control of contractions. Oxytocin levels were also raised in the cerebrospinal fluid during labour, indicating that oxytocin is released into the brain, as well as into the circulation. Oxytocin released into the brain induces beneficial adaptive effects during birth and postpartum. Oxytocin levels following infusion of synthetic oxytocin up to 10 mU/min were similar to oxytocin levels in physiological labour. Oxytocin levels doubled in response to doubling of the rate of infusion of synthetic oxytocin. Plasma oxytocin levels increase gradually during pregnancy, and during the first and second stages of labour, with increasing size and frequency of pulses of oxytocin. A large pulse of oxytocin occurs with birth. Oxytocin in the circulation stimulates uterine contractions and oxytocin released within the brain influences maternal physiology and behaviour during birth. Oxytocin given as an infusion does not cross into the mother's brain because of the blood brain barrier and does not influence brain function in the same way as oxytocin during normal labour does

Smart rollerski - radius pultrusion in application: Poster presentedt at 5th International Composites Conference, ICC 2019, 10. - 12. September 2019, Stuttgart, im Rahmen der Fachmesse COMPOSITES EUROPE

Lightweight applications made of fiber-reinforced plastics have been used in top-class sports for many years. With an innovative rollerski – developed in the joint project "SmartFrame +" funded by the BMBF – different target groups are addressed. On the one hand, users who are looking for fun and physical exercise. On the other hand, there are winter sports enthusiasts who want to improve their skiing skills during the summer break. Especially in this case, the challenge is to achieve a congruence in motion compared to the classic winter ski and thus to train the motor skills and muscle groups targeted. This will be supported by integrated sensors